The Pacers, who blew a lead in Saturday's Game 1 loss, put the contest away in the third quarter this time, erasing a 50-45 deficit with an extended 25-5 run.
Paul George contributed 17 points and eight rebounds, and Roy Hibbert hauled down 13 boards as Indiana evened the best-of-seven series 1-1.
The Magic were hampered by cold shooting, hitting only 35.5 percent from the field.
Glen Davis led Orlando with 18 points and 10 rebounds.
Game 3 will be Wednesday in Orlando.