Chicago had forged a 4-4 tie in the top of the frame on Starlin Castro's RBI single and a two-run homer by Bryan LaHair off Chad Qualls (1-0).
Philadelphia came right back when Scott Maine (0-1) hit Juan Pierre with a pitch with one out. Pierre went to third on Jimmy Rollins' single and Polanco then chased both of them home with a double down the left-field line.
Chicago starter Chris Volstad yielded four runs on eight hits over six full frames.
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