Rose scored 23 points to go with nine rebounds and nine assists in the Bulls' 103-91 playoff-opening win over Philadelphia Saturday.
But he had to be helped off the court with 1:10 left in the game after jump-stopping in the lane while throwing a pass. Rose crumpled to the floor and grabbed his left knee before being taken to the locker room.
He was later diagnosed with a torn anterior cruciate ligament.
"It's part of the game. There are going to be injuries," Bulls Coach Tom Thibodeau said. "A guy could get hurt in practice, a guy could get hurt in the first 5 minutes of the game. He can get hurt at the end of the game. He can get hurt any time, and you've got to deal with it."