Trailing 2-1 entering their final at-bat, the Cubs got one-out walks from Bryan LaHair and Geovany Soto off Cardinals closer Jason Motte (1-1). Both moved up a base on Steve Clevenger's groundout, and that set the table for Mather, who scalded a two-strike pitch up the middle to chase home both runners for the winning margin.
The rally handed a victory to Rafael Dolis (1-1), who tossed 1 2/3 innings of scoreless relief as Chicago took the first contest of a three-game set against the National League Central leaders.
St. Louis starter Jaime Garcia got a no-decision after shutting down the Cubs on one run over 7 2/3 innings.
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