Holiday later added a slam-dunk and finished with 17 points and seven assists for the Sixers, who won their second straight and were looking to clinch an Eastern Conference playoff spot.
Indiana, meanwhile, saw its seven-game winning streak snapped despite a season-high 32 points and 12 rebounds from David West.
Tyler Hansbrough netted 17 points off the bench while Paul George chipped in 16 and seven rebounds for the Pacers.
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