Reimold broke up a scoreless pitcher's duel in the sixth inning, pulling an 0-1 pitch from John Danks (1-2) into the left field stands with Robert Andino aboard. The next batter, Hardy, also yanked one out to left, and the Orioles held on to win their fourth game in five contests.
Wei-Yin Chen (1-0) earned his first major league win, holding the White Sox to two runs on six hits over 5 1/3 innings. Darren O'Day, Troy Patton and Luis Ayala combined for 2 2/3 frames of scoreless relief and Jim Johnson collected his fifth save for the O's.
Danks finished by allowing three runs on five hits over seven frames.
A.J. Pierzynski stroked a two-run double to provide Chicago's offense.