Orlando -- missing starters Dwight Howard and Glen Davis -- got 16 points and 13 assists from Jameer Nelson.
Earl Clark, also filling in for the injured stars, registered career highs of 14 points and 11 rebounds.
The Magic, who clinched a playoff berth Sunday, shot 53 percent from the field.
Philadelphia fell to 2-6 in April.
Jrue Holiday scored 18 points and dished off eight assists for the Sixers, who are tied with New York for the seventh seed in the Eastern Conference.