West grabbed 10 rebounds for Indiana, which jumped off to a 32-7 lead in the first period and never looked backed, cruising to its fifth straight victory.
Indiana strengthened its grip on homecourt advantage in the post-season with the Eastern Conference's third seed.
J.J. Barea had 14 points and nine assists for Minnesota, which stumbled to its 10th straight loss.
Derrick Williams and Michael Beasley put in 13 points each for the Timberwolves.
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