Andujar used a second-set tiebreaker to post a 6-1, 7-6 (7-5) victory over the seventh-seeded Ramos.
His only other ATP Tour title came in last year's Casablanca finals win over Italy's Potito Starace,
The third-seeded Spaniard improved to 2-3 in career finals with the triumph.
Ramos, meanwhile, was making his first-ever appearance in a final.
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