Russell Westbrook chipped in with 35 points and eight assists for Western Conference-leading Oklahoma City, which began a five-game road trip with a victory.
Minnesota, playing without all-star forward Kevin Love for the second straight game, dropped its ninth straight contest.
Michael Beasley put in 26 points while J.J. Barea added 24 and 10 assists for the Timberwolves.
Anthony Randolph supplied added 22 points and 11 rebounds in the loss.
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