Luol Deng added 19 points and 10 rebounds for the Bulls, who took the court without Rose, who continued nursing his aching ankle.
Chicago padded its position as top seed in the East playoffs to three games over Miami.
The Knicks slipped to eighth place in the East seedings, one game ahead of the Milwaukee Bucks.
J.R. Smith added 14 points for New York.
The Knicks shot 42.5 percent from the field and only scored 10 points in the second quarter.
Rosie O'Donnell unveils nearly 50-pound weight loss
Members of Congress to keep receiving porn magazine