Lohse (2-0), who took a no-hitter into the seventh inning of St. Louis' season-opening victory over Miami Wednesday, held the Reds to one run on four hits, walking two and striking out a pair.
Mitchell Boggs followed with two shutout relief frames and Jason Motte picked up his second save as the Cards won for the fifth time in six contests.
Cincinnati starter Mike Leake (0-1) surrendered three runs on seven hits through six innings.
Joey Votto got the only RBI for the Reds, who fell to 2-3.
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