Durant compiled his total in just three quarters, while James Harden chipped in 17 points off the bench for the Thunder, who trail San Antonio by percentage points atop the Western Conference.
The Spurs also got 15 points, six rebounds and six assists from Russell Westbrook in the victory.
Toronto lost its second straight despite Jose Calderon's 19 points and six assists.
DeMar DeRozan supplied 16 points for the Raptors.
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