The Serbian star wrapped up the victory on his first match point in the second-set tiebreaker when Murray hit his forehand long, improving to 20-2 on the year en route to his 30th career tour-level crown.
Djokovic was successful on 70 percent of his service points while Murray had just one break opportunity the entire match and fell to 5-8 all-time against the world No. 1 player.
Djokovic hadn't played since Wednesday after Rafael Nadal withdrew from Friday's scheduled semifinal match.
Murray fell to 1-2 in finals this year while appearing in his 33rd career ATP championship match.