Meeks, starting in place of injured guard Andre Iguodala, helped the Sixers grab a 1/2-game lead over idle Boston atop the Atlantic Division.
Jrue Holiday supplied 19 points and six assists while Lou Williams added 11 points, seven rebounds and seven assists for Philadelphia.
Anthony Parker scored 14 points to lead the Cavaliers, who dropped their fourth straight.
Former Titans kicker dies in car crash
UPI Sports Results for September 20, 2014