Higgins scored on a one-timer off a Jannik Hansen pass, and the Canucks celebrated their division title with a victory over the Avalanche.
Vancouver clinched its fourth straight Northwest crown earlier Saturday when the Calgary Flames fell to Dallas.
Higgins also scored in the second period and Mason Raymond added a tally for the Canucks, who improved to 99 points with win -- two fewer than St. Louis atop the Western Conference standings.
Roberto Luongo earned the victory with 38 saves.
The Avalanche, meanwhile, fell to 10th place in the tightly packed West, but remained just one point out of the eighth and final playoff spot.
Gabriel Landeskog and Jamie McGinn scored and Jean-Sebastien Giguere turned aside 29 shots for Colorado.