Wade scored 24 points, grabbed nine rebounds, handed out five assists and came up with three steals.
The Pistons turned the ball over 23 times, hit only 38 percent of their shots and found themselves trailing by 23 points at halftime. It was Detroit's fourth consecutive setback.
Brandon Knight had four 3-pointers and scored 18 points to lead the Pistons.
Miami won its 15th road game of the season, joining Chicago and Oklahoma City as the only teams in the NBA with that many wins away from home.
2014: The Year in Music [PHOTOS]