The 76ers had a three-game winning streak snapped while Indiana improved the third-best Eastern Conference home record to 13-5. Only Chicago and Miami have better home marks in the East.
Indiana had an eight-point advantage with 6:55 to play when it embarked on its game-clinching run.
Evan Turner made 9-of-11 shots from the field and led Philadelphia with 21. The 76ers committed 21 fouls to just eight for Indiana.