Jaroslav Halak blocked 33 shots for the Blues, who have won five straight and nine of their last 10.
Mark Letestu scored the only goal for the Blue Jackets, who lost both ends of a home-and-home series after a four-game winning streak.
Columbus goalie Curtis Sanford gave up both goals on 26 shots to take the loss.
Interpol investigating stolen passports on missing flight
Senate Democrats to pull all-nighter on climate change