Metta World Peace scored 14 points and Paul Gasol scored 13 to go with 13 rebounds and five assists for the Lakers, who shot 50.7 percent from the field and went 8-for-16 from 3-point range. Steve Blake had six assists and two steals for LA, which won its ninth straight game at Staples Center.
The Celtics had five players in double figures, led by Rajon Rondo with 24 points and 10 assists. Ray Allen scored 27 and Kevin Garnett finished with 14 points and 11 rebounds for Boston, which shot 47 percent from the field but just 35.3 percent from long range.
Bryant scored 10 in the fourth quarter and put the Lakers ahead with a jump shot with 41.7 seconds left to play that came during an 8-0 Lakers run at the finish.
Paul Pierce and Rondo both missed on 3-point tries in the closing seconds. Pierce finished with 13 points and nine assists for the Celtics, who lost for just the second time in eight games.