After the Blue Jackets went up 2-1 early in the third period on a shorthanded, unassisted goal by Derek MacKenzie, the Red Wings erupted for four unanswered tallies to win going away.
Joey MacDonald earned the triumph with 28 saves.
Rick Nash also scored for Columbus.
Curtis Sanford yielded five goals on 25 shots for the losers.
Gal Gadot cast as Wonder Woman for 'Batman vs. Superman'
Jordana Brewster on Paul Walker: 'He was an enormous presence in my life'