Durant made 12-of-22 shots from the field in pushing the Thunder to their fifth straight win.
It was the final game played in the NBA before the All-Star break and Oklahoma City heads into the showcase weekend tied with Miami for the best record in the league at 27-7. The Chicago Bulls are 27-8.
Russell Westbrook added 19 points and Serge Ibaka had 11 points and 13 rebounds for Oklahoma City.
Kobe Bryant scored 24 for the Lakers, but he made just 7-of-24 from the field. Bryant got to the foul line 11 times and hit 10 of them.
Members of Congress to keep receiving porn magazine
Iranian woman stops the execution of son's killer