Roddick, who withdrew with an injury during the second round of the Australian Open and lost in the quarterfinals to Denis Istomin at the SAP Classic last week, was ousted 7-6 (10-8), 7-5. Roddick was the No. 2 seed in this event.
Milos Raonic, the fourth seed, won over Ernests Gulbis 6-2, 7-6 (7-3) to set up a confrontation with Philipp Petzschner.
Petzschner ousted Julien Benneteau 7-6 (7-5), 7-6 (8-6).
In other matches Wednesday Jurgen Melzer outlasted Istomin 6-7 (2-7), 6-3, 7-6 (7-4), Kevin Anderson defeated Robby Ginepri 7-5, 6-3 and Lukasz Kubot eliminated Jesse Levin 7-6 (7-2), 6-4.
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