The Spurs bounced back after having their 11-game winning streak snapped Tuesday in Portland.
All five San Antonio starters scored in double figures and the Spurs dashed to a 26-7 lead. The advantage grew to 26 points by halftime.
San Antonio completed its nine-game road trip with an 8-1 record.
Denver lost for the 10th time in 13 games. Corey Brewer led the Nuggets with 23 points.
Video of Victoria’s Secret models trying to 'twerk' hits Instagram
Susan Sarandon: I was stoned at almost every awards show