The Heat put together an enthusiastic effort to shut down the Knicks, who had won nine of their previous 11 but could shoot only 39 percent from the field.
Miami squelched rising star Jeremy Lin, who had what was easily his worst game since moving into the starting lineup Feb. 8. The New York point guard made just 1-of-11 shots from the field, scored eight points and turned the ball over eight times.
Bosh scored 25 points, Wade had 22 and James produced 20. Miami outscored the Knicks by 10 in the third period to take a 14-point lead into the final quarter.
New York stayed in the contest until late, thanks to a 19-of-22 effort from the foul line. Carmelo Anthony had 19 points to lead the Knicks and J.R. Smith scored 14.