The Pacers defeated the Bobcats for the second time in four days and handed Charlotte its 18th loss in 19 games.
Charlotte came back from an eight-point halftime deficit to tie the game midway through the third period, but Indiana outscored the Bobcats 40-26 the rest of the way.
Danny Granger added 12 for the Pacers while Darren Collision, Paul George and Dahntay Jones all had 10. Indiana has won four in a row, equaling its longest streak of the season.
Corey Maggette scored 20 points for the Bobcats, who have lost all of their last nine meetings with Indiana.
Celebrity Breakups and divorces of 2014 [PHOTOS]