The Pacers defeated the Bobcats for the second time in four days and handed Charlotte its 18th loss in 19 games.
Charlotte came back from an eight-point halftime deficit to tie the game midway through the third period, but Indiana outscored the Bobcats 40-26 the rest of the way.
Danny Granger added 12 for the Pacers while Darren Collision, Paul George and Dahntay Jones all had 10. Indiana has won four in a row, equaling its longest streak of the season.
Corey Maggette scored 20 points for the Bobcats, who have lost all of their last nine meetings with Indiana.