Jamison pumped in 32 points and grabbed 10 rebounds while Irving chipped in with 25 points and a career-high eight assists for the Cavs.
Cleveland nailed down its third win in four games with the help of Alonzo Gee's 16 points and 11 rebounds.
The Pistons lost for only the first time in four games despite 24 points from Brandon Knight.
Greg Monroe added 19 and 11 rebounds for Detroit.
Moore to attend retreat in to avoid Kutcher's wedding
'How to Train Your Dragon 2' releases 5-minute clip