Roy scored twice and added an assist while Pominville donated a marker and two assists as the Sabres beat the Penguins for the first time in five meetings.
Ryan Miller earned the victory with 24 saves.
Buffalo chased starting netminder Pittsburgh Brent Johnson with three goals on 12 shots. Marc-Andre Fleury relieved but also wasn't effective, letting in three tallies on 12 shots.
Jordan Stall and Deryk Engelland scored for Pittsburgh.
|Additional Sports News Stories|
WASHINGTON, May 19 (UPI) --Television actress Christine White has died in Washington, her representatives announced. She was 86.
MOSCOW, May 19 (UPI) --A biological research satellite capsule returned to Earth Sunday with its mice, gerbils, geckos and plants after a 30-day flight, Russian space officials said.