Danny Granger and David West each notched 14 points, Tyler Hansbrough added 13 and Dahntay Jones chipped in with 12 for the Pacers, who continued their rebound from a five-game skid with a second consecutive win.
Darren Collison also netted 10 points for Indiana.
The Bobcats, who snapped a franchise-record 16-game losing streak Friday, fell back into the loss column against the Pacers, trailing by as many as 44 points during the contest.
Derrick Brown scored 16 points and Kemba Walker added 15 and five assists for Charlotte.
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