Perry's 32-hole total of 18-under 126 shattered the former course mark by four shots and gave him a three-stroke lead over second-place Larry Mize.
Mize turned in a round of 5-under 67, but still was looking up a Perry at minus-15.
Tom Lehman registered a 6-under 66 Saturday in Naples, Fla., grabbing sole possession of third place at 14-under 130.
Alone in fourth one shot further back was Bernhard Langer, who fired a 7-under 65.
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