The Bucks had a 10-point lead with 9:45 to play in the game and managed only three points the rest of the way. Milwaukee was held scoreless for the last 5:56.
The game-closing 22-3 run brought Orlando its fourth consecutive win while Milwaukee has dropped four in a row.
Carlos Delfino led Milwaukee with 16 points. The Bucks shot just 20 percent from the field in the final period, during which they scored 11 points.