Anderson went 7-of-10 from beyond the arc and scored 27 points. Orlando was 15-of-25 from long range, with Jason Richardson adding four 3-pointers.
Dwight Howard added 17 points with 14 rebounds as part of Orlando's third straight victory and its seventh win in nine games. Jameer Nelson equaled a career best with 14 assists while producing 12 points for the Magic.
Division-leading Philadelphia suffered just its 10th loss of the season in 30 games, having won its previous two. Lou Williams led the 76ers with 21 points and seven assists off the bench.
Philadelphia closed out a three-game road trip and will host Dallas Friday before going back on the road for four more.