The Cavaliers had an 18-point lead going into the fourth quarter and easily held on against an Indiana team struggling through an outbreak of injuries that has resulted in a five-game losing streak.
Irving suffered a concussion Feb. 7 when he was kneed in the head during a game against Miami. He hit 8-of-12 from the field and played 37 minutes in his return.
Semih Erden had a career-best 18 points for the Cavaliers while Ramon Sessions and Antawn Jamison had 13 each.
Indiana shot only 36 percent from the field.
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