James also hauled down 13 rebounds and added six assists. Wade collected all of his points during a big first half for Miami.
Chris Bosh contributed 14 points and 16 boards as the Heat cruised after outscoring Atlanta 63-41 in the opening 40 minutes.
Miami sank 26 foul shots to only six for the Hawks and outrebounded them 52-38 for the game.
Atlanta was paced by 17 points off the bench from Willie Green.
Joe Johnson struck for 12 points for the Hawks.
Former Titans kicker dies in car crash
UPI Sports Results for September 20, 2014