James also hauled down 13 rebounds and added six assists. Wade collected all of his points during a big first half for Miami.
Chris Bosh contributed 14 points and 16 boards as the Heat cruised after outscoring Atlanta 63-41 in the opening 40 minutes.
Miami sank 26 foul shots to only six for the Hawks and outrebounded them 52-38 for the game.
Atlanta was paced by 17 points off the bench from Willie Green.
Joe Johnson struck for 12 points for the Hawks.