Serra ousted Tobias Kamke 6-3, 6-3 on the strength of three service breaks in each set in the tournament's final first-round match. Serra won more than half (26-of-49) of the points when receiving serve.
His second-round foe is Berdych. The top four seeds were given first-round byes.
All three of the seeded players who were on Tuesday's schedule won. Fifth-seeded Feliciano Lopez pounded out 19 aces in a 6-4, 7-6 (9-7) win over Igor Kunitsyn. Lopez won 71 percent of the points on serve.
Also Tuesday, Nicolas Mahut beat Albert Ramos 6-3, 6-2; Edouard Roger-Vasselin got by Roberto Bautista-Agut 7-5, 6-2; Paul-Henri Mathieu advanced over Cedrik-Marcel Stebe 6-4, 6-4; Michael Russell took a 6-3, 7-5 victory over Adrian Mannarino; and Flavio Cipolla outlasted Marc Gicquel 1-6, 6-4, 7-5.