Mike Dunleavy and Ersan Ilyasova each came off the bench to contribute 15 points for the Bucks, who put the game away with a 17-0 run spanning the first and second quarters.
Kobe Bryant registered 27 points, nine assists and eight rebounds for the Lakers, who fell to 1-7 on the road this season.
Pau Gasol added 12 points and 15 rebounds for Los Angeles.
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