Howard stopped 14 straight St. Louis shots over the final two periods and logged an NHL-best 30th victory as the Red Wings extended their team-record home ice success string.
The streak is the third-longest in NHL history -- three short of matching a record shared by the 1929-30 Boston Bruins and 1975-76 Philadelphia Flyers.
The Blues absorbed their first regulation loss in January.
Scott Nichol scored and Jaroslav Halak stopped 25-of-28 shots for St. Louis.
Notable deaths of 2014 [PHOTOS]
Michael Sam cut from the Dallas Cowboys