The Pistons put together a late run that included several critical free throws down the stretch and held off the Trail Blazers for the victory.
Tayshaun Prince used his 17 points to help Detroit win only its second game in 12 tries.
LaMarcus Aldridge led the Blazers 25 points.
Portland wrapped up a long, six-game road trip with a 2-4 mark.
2014: The Year in Music [PHOTOS]