Playing their third straight game without Derrick Rose, the Bulls ran the NBA's best record to 14-3. Rose, the league's defending MVP, has been listed as day-to-day with a toe injury.
His absence did not slow down the Bulls, who shot 55 percent from the field, missed only once in 17 attempts from the foul line and made 6-of-9 from 3-point range.
Chicago had an 18-point lead with 6:30 to go in the third period and then held the Cavaliers to just four points for the rest of the quarter.
Anderson Varejao had 14 points to pace the Cavaliers.