The Heat built a 15-point halftime lead and owned as much as a 20-point advantage early in the fourth period.
The anticipated matchup appeared as if it might be missing one of its star attractions, but James produced a solid performance that included eight rebounds and eight assists. He made 17-of-27 shots from the field.
James got the best of the Lakers' Kobe Bryant, who hit 8-of-21 from the field and scored 24 points.
After reaching at least 30 points in eight straight games, Bryant has gone 15-of-43 in his last two outings. He scored 14 this week in a win over Dallas.