The Sabres lost their 10th consecutive road contest, with Jhonas Enroth giving up all six goals on 35 shots.
Jason Pominville delivered both Buffalo goals.
Corey Crawford made 27 saves for the Blackhawks, who jumped over both St. Louis and Detroit to take the lead by a point in the Central Division.
Gal Gadot cast as Wonder Woman for 'Batman vs. Superman'
Benedict Cumberbatch's dramatic reading of R. Kelly lyrics is just what you need