Jimmy Howard turned aside 27 shots to log his fifth shutout of the season for the Red Wings, who stayed unbeaten on their home ice since a 4-1 loss to Calgary Nov. 3 -- a franchise record.
The Sabres dropped their ninth consecutive road contest.
Ryan Miller started in goal for Buffalo and was yanked in the second period after surrendering all five goals on just 14 shots.
Jhonas Enroth relieved and stopped 12-of-12 Detroit tries the rest of the way.
2014: NFL Cheerleaders [PHOTOS]
Michael Sam cut from the Dallas Cowboys