The Bulls broke open a close game in the second half thanks, in part, to Carlos Boozer's 17 points and 13 rebounds.
Taj Gibson also helped Chicago raise its home record to 5-0 with 11 points with 12 boards.
The Raptors missed leading scorer Andrea Bargnani, who was out for the second straight game with a strained left calf.
Leandro Barbosa and DeMar DeRozan each netted 15 points, but it wasn't enough to prevent Toronto's sixth loss in seven games.
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