The Sabres ended a three-game skid after letting an early two-goal lead slip away. Toronto had won four in a row.
Pominville's goal, his 15th of the season, came against Jonas Gustavsson, who stopped 22-of-25 shots.
The win went to Ryan Miller, who made 24 saves. Miller, who has won at lest 34 games in each of his last five seasons, has just 11 victories this season.
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