The Rockets had played five of their previous six games on the road, but came through down the stretch in their return home.
It was a tie game with 3 minutes left in the third period and the Rockets outscored the Kings 12-3 during the rest of the quarter.
Lowry had four free throws and a 3-pointer in that stretch and Houston pulled away in the fourth quarter.
Sacramento, which played the third contest in a five-game road trip, got 27 points from Tyreke Evans.
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