West, a free-agent acquisition for the Pacers, joined Roy Hibbert and Tyler Hansbrough in notching double-doubles -- Hansbrough had 15 points and 13 rebounds while Hibbert added 16 points and 14 for Indiana.
The Pacers logged a win in head Coach Frank Vogel's first season-opener behind the bench. He took over from the fired Jim O'Brien late last season and led the Pacers to their first post-season appearance since 2006.
The Pistons fell in the first head coaching appearance for Lawrence Frank.
Detroit was led by Jonas Jerebko and Rodney Stuckey, with 17 points each.
Campus cop fatally shoots Texas student during traffic stop
Police: Sword-wielding man demanded free tacos