Hasselbeck went 24-of-40 through the air as Tennessee (8-7) bounced back from last week's loss to Indianapolis.
The win allowed the Titans to remain one game behind Cincinnati for the AFC's final wild card spot.
The Jaguars (4-11) were led by Maurice Jones-Drew with 103 rushing yards and a TD on 24 carries, but Blaine Gabbert was held to 198 passing yards and one interception in the loss.
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