Flacco went 11-of-24 through the air for 132 yards with an interception for the Ravens (11-4), who finished 8-0 at M&T Bank Stadium -- the first time in franchise history the club as racked up undefeated home record.
Ray Rice compiled 87 yards on 23 carries and added a receiving touchdown as Baltimore put itself in position to claim the AFC North with a win or a Pittsburgh loss next week.
The Browns (4-11), meanwhile, dropped their eighth straight against the Ravens.
Peyton Hillis carried the ball 24 times for 112 yards in the loss.
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