Malkin completed his hat trick with a power-play tally 11:43 into the final period, racking up his fourth career five-point game. The Pittsburgh center continued to help make up for the absence of Penguins captain Sidney Crosby, notching six goals and six assists in the last five games.
He scored twice in the first period as the Pens netted three consecutive goals within the game's first 10 minutes to set the tone.
Buffalo's Ryan Miller was chased from the game midway through the second period after allowing five goals on 15 shots. Backup Jhonas Enroth didn't fare much better, stopping 8-of-11 the rest of the way.