The defensive back managed to keep both feet in the end zone before falling out of bounds, handing the Panthers (3-8) their first win in 13 road games.
DeAngelo Williams gained 69 yards with two touchdowns on 15 carries while Cam Newton completed 20-of-27 passes for 208 yards to go along with 53 rushing yards and a score on the ground.
The Colts, meanwhile, fell to 0-11 for the first time since 1986.
Painter finished with a 15-of-29 passing performance for 226 yards and a touchdown while Reggie Wayne made five grabs for 122 yards and a score.
Notable deaths of 2014 [PHOTOS]
Michael Sam cut from the Dallas Cowboys